'Quarantine' is a linear 3D hack-and-slash game for consoles and PC. The game's main appeal is exploring various houses turned into arenas by a new type of disease possessing the weak willed, as they stop the disease from spreading further.

The game controls a mercenary medic with a syringe bayonet as he goes through several missions with different types of enemies that try to get the player as sick as their host while they escape! The player must defeat all enemies that appear within a certain time frame (including every level's boss battle) or the disease will spread, rendering the mission a failure. Taking too much damage will render the player character sick, causing a game over as well.

The main character can dodge, dash, launch enemies into the air and perform various stabbing attacks with various button combinations. Evade attack at just the right time for bonus points!

At the end of every level, players are scored from C to S based on their performance. The player can unlock costumes every few S rankings they achieve. Along with bragging rights, of course.