An RPG centered around Worm, a web serial by Wildbow, which can be found at https://parahumans.wordpress.com/

I'd like to see this as an computer based rpg for the graphics, but given the possible range of parahuman abilities there would need to be a database as well as a way to collect and add new/suggested powers. Given that the powers and their strength is also assigned completely at random, you'd get a lot of players restarting until they got a power they liked. Given that the main struggle is meant to be taking a seemingly worthless power and using it in creative ways, this could also strain the boundaries of the standard RPG. It'd probably work better on pen and paper. You'd start off as a normal human, wind up in a situation that could cause a trigger event and recieve a random power... or go through the game without one. Given the level of opponents offered in the story, every fight would be challenging. Fighting Lung, for example, would force the player/s to work under a time or turn limit, as his power escalates in response to threats. Fighting Panacea would be near suicide for everyone, considering that she's one bad day from wiping out humanity with an artificially created virus. The number of possible opponents would keep things interesting, as well as the possibilities for role-playing. Whether a villain, vigilante, rouge, independent hero or member of the protectorate/various gangs/slaughterhouse nine/your newly created group you haven't named yet, you'd have a totally different set of powers and challenges to work with each time.

"We're s- so very small, in the end."

Image sourced from http://undersiders.deviantart.com/art/Metamorphosi..., by RespicePostTe