'Diagnosis' is a puzzle game played on the PC, in which the player is a medical doctor in a popular hospital clinic. They must correctly diagnose patients and prescribe treatments. The catch is that the player only 5 minutes of in-game time, corresponding to 1 minute of real life time to do so. Each day at the clinic represents a level of the game, the player is given approximately 10 patients per level.

When diagnosing, the player has access to reported symptoms by the player, medical history, and a simplified 'dictionary' of illnesses. When prescribing treatments the player must ensure that it will not trigger any allergies or have a negative effect due to an aspect of the patient's history.

Each level increases the difficulty of each illness, and the number of possible complexities when prescribing treatments. At the end of each level, the player is given points corresponding to how many patients were treated well. These points can be invested in a skill-tree-like progression of new medicines and other treatments, which can be advantageous in future levels.

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